Questions for Other Labs

Other contract labs now say they too can provide biophysical analysis services such as AUC or CD. Some of them don't actually do the work themselves, or they do it in some university laboratory. Some make statements on their web pages that show they do not understand the basic principles of the methods.

Having the equipment, or access to it, is simply not enough---these are highly specialized methods requiring significant experience to properly gather and interpret the data. The key questions you need to ask are:

Who is doing the work?

  • Who actually runs the experiments? Who analyzes and interprets the data?
  • What is their experience with this technique?
  • What is their publication record with this method?
  • Do they have a track record of innovation with this method?
  • How many different proteins have they worked with?
  • Do they have experience working in the biotech industry, doing product development?

What is the company's track record?

  • How long have they been doing this type of analysis?
  • How many projects have they completed, for how many different clients, on how many different products?

Where are they doing the work? With what equipment?

  • If the work is being done at some university or institute facility, how can you be sure the equipment is working properly?
    • We have learned from decades of experience that for these methods OQ and/or other testing by the instrument manufacturers is simply insufficient to guarantee reliable results.
  • Does the contract lab have its own sample cells to ensure the quality of the cells and that they are properly cleaned to avoid cross-contamination?
  • For AUC, does the contract lab have a cell alignment tool to help improve data reproducibility?
  • How is data integrity and security handled?

The A.P.L. difference!

  • At A.P.L. all work is done in our facility, on our own dedicated equipment, and by our Ph.D. principal scientists, not a technician
  • What other contract lab can say the people doing the experiments and interpreting the data each average 28 years experience and over 130 publications?
  • A.P.L. has been doing this for over 18 years. We have completed more than 2000 projects on literally hundreds of products for 350+ companies, institutes, and universities
  • We have no outside investors to satisfy, and no marketing staff to support. We will never push you to run studies that aren't truly needed.
  • At A.P.L. we don't just run samples, we work collaboratively with our clients

    • we want to be sure our clients understand the data we provide and are able to present the results to their colleagues and managers in a meaningful way that will influence decision making

    • our reports explain the data and provide necessary background so your scientists can fully use the results

    • if needed, we can present the data at your site and can contribute our expertise as consultants to interpreting its implications for the development of your product

 

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